GEGE: Çizge Gömülümleriyle Gen Esaslılığını Tahmin Etme

A gene is considered essential if its function indispensable for the viability or reproductive success of a cell an organism. Distinguishing genes from non-essential ones fundamental question in genetics, and it key to understanding minimal set functional requirements Knowledge also crucial drug discovery. Several reports literature show that location protein-protein interaction network correlated with target gene’s essentiality. Here, we ask whether node embeddings (PPI) can help predict Our results on predicting human essentiality alone achieve up 88% AUC score, which better than using topological features characterize properties other previous work’s results. We that, when combined homology information across species, this performance reaches 89% AUC. work shows protein PPI capture connectivity patterns proteins improve predictions.